![]() That govern the efficacy of synthetic receptors while generating clinically relevantĮngineering protein- and cell-based therapies.Įngineering a better understanding of synthetic receptors: Synthetic receptors, such as CARs or inverted cytokine receptors, are often engineeredĮmpirically, fusing natural and engineered domains with minimal optimization. To gain a fundamental understanding of the biophysical and biochemical parameters Limitations of the current CAR platform motivate further study. While efficacious in a subset of diseases, Of an antibody with the cytotoxic capacity of a T cell receptor, has laid the groundworkįor successful engineered cell therapies. The chimeric antigen receptor (CAR), a synthetic receptor combining the specificity Synthetic receptors and cell engineering have invigorated the immunotherapy field. Understanding the building blocks of potent synthetic receptors.Re-engineering natural proteins for therapeutic benefit.Developing better high-throughput platforms for protein and cell engineering. ![]() Therapies by combining high-throughput experimental approaches and computational proteinĮngineering to gain unique insight into sequence-function and structure-function relationships. The Stern research group aims to understand and engineer better protein- and cell-based Research Overview: Engineering Protein- and Cell-Based Therapies for Disease B.S., Chemical Engineering, Chemistry, Virginia Tech.Ph.D., Chemical Engineering, University of Minnesota, Twin Cities.Postdoctoral Fellowship: Beckman Research Institute of the City of Hope.
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